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KMID : 0941820030130020067
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Korean Journal of Clinical Pharmacy
2003 Volume.13 No. 2 p.67 ~ p.71
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Drug Interaction of Metformin and Aspirin in Rabbits
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Choi Jun-Shik
Choe In
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Abstract
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The purpose of this study was to investigate the effect of aspirin (5, 10, 20 mg/kg) on the pharmacokinetics of metformin (15;mg/kg) in rabbits. The plasma concentration of metformin was decreased significantly (p<0.05) by co-administration of aspirin (10, 20 mg/kg) compared with control. Area under the plasma concentration-time curve (AUC) of metformin was decreased significantly (p<0.05) by co-administration of aspirin (10, 20mg/kg) compared with control. Relative bioavailability (R.B%) of metformin by co-administration was 79.3 (5 mg/kg), 57.5 (10 mg/kg) and 62.5 (20 mg/kg). Peak plasma concentration of metformin was significantly (p<0.05) decreased by co-administration of aspirin (10, 20 mg/kg) compared with control. The elimination rate constant (K_{el}) of metformin was increased by co-administration of aspirin (10, 20 mg/kg) compared with control. The terminal half-lifes (t_{1/2}) and mean resident time (MRT) of metformin by co-administration of aspirin (10, 20 mg/kg) were decreased significantly (p<0.05) compared with control. It is considered that the significantly decreased plasma concentration and AUC of metrormin is due to increase of elimination in urine acidified by co-administration of aspirin. The results suggest that the dosage of metformin should be adjusted when metformin is co-administered with aspirin in the clinical situation.
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KEYWORD
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Interaction, pharmacokinetics, metformin, aspirin
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